Biochemical Parameters and Indicators of Oxidative Stress in Indian Periodontitis Patients

Abstract

Periodontal disease, also known as chronic periodontitis, causes inflammation in the periodontium. Biochemical oxidative stress markers were measured and compared between patients suffering from chronic periodontitis & healthy controls& the impact of nonsurgical periodontal treatment was assessed. A total of 65 healthy volunteers and 5 patients suffering from chronic periodontitis were chosen at random to take part in the study. Periodontal health was determined by measuring clinical attachment losses, gingival score, bacterial index, and gum bleeding (CAL). Biochemical indicators included vitamin C, peroxidation, CRP, red blood cell superoxide dismutase (GPx), and total antioxidant capacity (TAOC). Non-operative periodontal therapy (scaling & root planing; SRP) was used to treat patients with chronic periodontitis, and patients were checked up on 3 months later. Patients suffering from chronic periodontitis had considerably higher levels of CRP, MDA, and RBC-SOD compared to controls, while they had significantly lower amounts of TAOC, GPx, or vitamin C. Biochemical and clinical oxidative stress markers were considerably reduced in patients treated with SRP for periodontitis. Patients suffering from chronic periodontitis have elevated levels of inflammation and oxidative stress. With SRP treatment, the systemic oxidant:antioxidant equilibrium is restored and the inflammatory burden is lessened. Periodontitis is an inflammatory disease, and SRP treatment may be helpful in its management and prevention.