Symptoms of Sickle Cell Disease in Children Include Oxidative Stress, Antioxidant Efficiency, Biomolecule Damage and Inflammation

Abstract

The etiology and consequences of sickle cell disease (SCD) are greatly impacted by oxidative stress. At birth, sickle cell is present. A kid is born with sickle cell anaemia if they receive two copies of a sickle cell gene, each from each parent. Endothelial dysfunction and severe inflammation have both been connected to the oxidative stress that is a typical concern for SCD patients. Catalase or superoxide dismutase (SOD) were two antioxidant enzymes that can be helpful in reducing damage. The oxidative processes have a major part in the pathogenesis of the disease. The primary treatment of SCD is blood transfusions, although receiving multiple transfusions at once can lead to iron excess. Patients with SCD lack sufficient evidence linking oxidative stress, hemolyticanemia, or insulin resistance. Hemolytic anaemia, heightened infection risk, and vaso-occlusion are all symptoms of sickle cell disease (a hemoglobinopathy) that reduce both life wellbeing and quality of life. Oxidative stress is more prevalent in patients with sickle cell disease and has been linked to hemolysis, vasoocclusion, and organ loss. ROS or their metabolites may serve as targets for antioxidant treatment or as disease severity indicators.