Values of the Bedside Ultrasound Measurement of Aortic Peak Flow Velocity Variability Combined with PLR in Predicting the Volume Responsiveness in Patients with Septic Shock

Abstract

The value of the bedside ultrasound measurement of aortic peak flow velocity variability (△VpeakAO) combined with passive leg raising test (PLR) in predicting the volume responsiveness was investigated in patients with septic shock. Eighty two patients with septic shock admitted in our hospital from January 2018 to January 2021 were selected. △VpeakAO values before and after PLR and after volume loading test (VE) were measured by a bedside
ultrasound instrument. The △VpeakAO values were calculated and the stroke volume (SV) was monitored, and according to the changes of SV after VE, the patients were divided into a response group (△SV ≥ 15%) and a non-response group (△SV < 15%). The results showed that the SV and △VpeakAO in the response group were lower than those in the non-response group after PLR and VE (P < 0.05), the SV and △VpeakAO in the response group after PLR and VE were higher than those before PLR (P < 0.05), and the △VpeakAO in the response group
was higher than that in the non-response group after PLR (P < 0.05). The ROC analysis showed that the best cut-off point of △VpeakAO-PLR was 11.09%, and the sensitivity was 88.24%, the specificity was 91.67% and the area under the curve (AUC) was 0.866. These results indicate that the bedside ultrasound measurement of △VpeakAO combined with PLR can effectively predict the volume responsiveness of patients with septic shock, with a guiding value in fluid resuscitation therapy.